Mechanism of global functional recovery despite sustained postischemic regional stunning.
نویسندگان
چکیده
منابع مشابه
Mechanism of global functional recovery despite sustained postischemic regional stunning.
BACKGROUND The mechanisms whereby reperfusion of a 20-minute coronary occlusion result in global functional recovery despite persistent regional dysfunction were studied in 11 open-chest reflex-blocked dogs. METHODS AND RESULTS Pressure-volume and pressure-thickness relations were simultaneously determined before, during, and after reperfusion of left anterior descending artery (LAD) occlusio...
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Among the numerous mechanisms proposed for myocardial stunning, three appear to be more plausible: 1) generation of oxygen radicals, 2) calcium overload, and 3) excitation-contraction uncoupling. First, the evidence for a pathogenetic role of oxygen-derived free radicals in myocardial stunning is overwhelming. In the setting of a single 15-minute coronary occlusion, mitigation of stunning by an...
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Whereas activation of ATP-dependent potassium (K(ATP)) channels greatly improves postischemic myocardial recovery, the final effector mechanism for K(ATP) channel-induced cardioprotection remains elusive. RhoA is a GTPase that regulates a variety of cellular processes known to be involved with K(ATP) channel cardioprotection. Our goal was to determine whether the activity of a key rhoA effector...
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Habitat restoration is a key measure to counteract negative impacts on biodiversity from habitat loss and fragmentation. To assess success in restoring not only biodiversity, but also functionality of communities, we should take into account the re-assembly of species trait composition across taxa. Attaining such functional restoration would depend on the landscape context, vegetation structure...
متن کاملPersistent changes in myocardial glucose metabolism in vivo during reperfusion of a limited-duration coronary occlusion.
BACKGROUND Rapid reperfusion of an occluded coronary artery salvages regional mechanical function, but this benefit may not be realized for hours or days because of postischemic stunning. Recovery from stunning is incompletely understood but may involve adaptive changes in heart glucose metabolism. METHODS AND RESULTS To examine whether reversible coronary occlusion produces sustained changes...
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ژورنال
عنوان ژورنال: Circulation
سال: 1992
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.85.2.816